Table 2.
Univariable and multivariable logistic regression model of patient and tumour characteristics associated with performance of MILR minor resections in patients who underwent liver resection for CRLM between 2014 and 2021 in the Netherlands. Multilevel logistic regression model with individuals nested for year of surgery
| Factor | Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|---|
| N | OR | 95% CI | p-value | aOR | 95% CI | p-value | |
| Sex | 0.71 | ||||||
| Male | 2820 | 1 | |||||
| Female | 1654 | 0.97 | 0.86–1.10 | ||||
| Missing* | 14 | ||||||
| Age (years) | 0.01 | 0.63 | |||||
| < 50 | 302 | 1 | 1 | ||||
| 50–64 | 1574 | 1.01 | 0.78–1.31 | 0.94 | 0.83 | 0.61–1.12 | 0.22 |
| 65–80 | 2230 | 1.18 | 0.92–1.52 | 0.19 | 0.89 | 0.66–1.20 | 0.44 |
| > 80 | 382 | 1.39 | 1.01–1.90 | 0.03 | 0.87 | 0.59–1.24 | 0.41 |
| Charlson Comorbidity Index (CCI) | 0.02 | 0.39 | |||||
| CCI 0/1 | 3267 | 1 | 1 | ||||
| CCI 2 + | 1221 | 1.16 | 1.01–1.33 | 1.07 | 0.91–1.26 | ||
| BMI** | 0.22 | ||||||
| Mean (SD) | 1.01 | 0.99–1.02 | |||||
| Missing | |||||||
| ASA score* | < 0.001 | 0.22 | |||||
| ASA 1/2 | 3390 | 1 | 1 | ||||
| ASA 3 + | 1041 | 1.31 | 1.13–1.51 | 1.11 | 0.94–1.32 | ||
| Missing* | 57 | ||||||
| Histopathology liver parenchyma £ | 0.004 | 0.81 | |||||
| Normal liver | 3023 | 1 | 1 | 1 | |||
| Liver disease | 921 | 0.79 | 0.68–0.93 | 0.004 | 1.06 | 0.88–1.27 | 0.55 |
| Missing | 544 | 0.81 | 0.66–0.98 | 0.03 | 1.98 | 0.77–1.27 | 0.84 |
| Preoperative chemotherapy | < 0.001 | < 0.001 | |||||
| No | 3156 | 1 | 1 | ||||
| Yes | 1066 | 0.31 | 0.26–0.36 | < 0.001 | 0.61 | 0.50–0.75 | < 0.001 |
| Missing | 266 | 0.30 | 0.22–0.40 | < 0.001 | 0.42 | 0.29–0.59 | < 0.001 |
| Number of lesions | < 0.001 | < 0.001 | |||||
| 1 | 2145 | 1 | 1 | 1 | |||
| 2 | 947 | 0.48 | 0.41–0.57 | < 0.001 | 0.56 | 0.46–0.68 | < 0.001 |
| 3 | 458 | 0.28 | 0.22–0.36 | < 0.001 | 0.34 | 0.26–0.45 | < 0.001 |
| 4 | 278 | 0.17 | 0.12–0.24 | < 0.001 | 0.22 | 0.15–0.33 | < 0.001 |
| 5 | 211 | 0.16 | 0.11–0.24 | < 0.001 | 0.19 | 0.12–0.30 | < 0.001 |
| > 5 | 358 | 0.09 | 0.06–0.13 | < 0.001 | 0.16 | 0.10–0.24 | < 0.001 |
| Missing* | 91 | ||||||
| Diameter of largest CRLM in mm | < 0.001 | ||||||
| < 20 | 1411 | 1 | 1 | ||||
| 20–34 | 1622 | 0.67 | 0.57–0.77 | < 0.001 | 0.70 | 0.59–0.83 | < 0.001 |
| 35–54 | 745 | 0.51 | 0.42–0.61 | < 0.001 | 0.49 | 0.40–0.61 | < 0.001 |
| 55–998 | 298 | 0.32 | 0.23–0.43 | < 0.001 | 0.32 | 0.23–0.44 | < 0.001 |
| Missing | 412 | 0.68 | 0.54–0.85 | < 0.001 | 0.82 | 0.62–1.09 | 0.16 |
| Bilobar disease | < 0.001 | ||||||
| No | 2028 | 1 | 1 | ||||
| Yes | 1730 | 0.22 | 0.19–0.36 | < 0.001 | 0.81 | 0.65–1.01 | 0.056 |
| Missing | 730 | 0.47 | 0.39–0.56 | < 0.001 | 1.06 | 0.80–1.41 | 0.69 |
| Location of primary tumour | 0.001 | ||||||
| Colon | 2905 | 1 | 1 | ||||
| Rectal | 1577 | 1.23 | 1.08–1.39 | 1.39 | 1.20–1.61 | < 0.001 | |
| Missing* | 6 | ||||||
| Timing of metastases | < 0.001 | 0.007 | |||||
| Metachronous | 2412 | 1 | 1 | ||||
| Synchronous | 2076 | 0.68–0.87 | 1.23 | 1.06–1.43 | |||
| Missing* | |||||||
| Extrahepatic disease | 0.003 | 0.051 | |||||
| No | 3806 | 1 | 1 | ||||
| Yes | 588 | 0.76 | 0.63–0.91 | 0.81 | 0.65–1.01 | ||
| Missing* | 94 | ||||||
| Type of hospital** | < 0.001 | < 0.001 | |||||
| Other hospitals | 2573 | 1 | 1 | ||||
| Tertiary centres | 1951 | 0.50 | 0.44–0.57 | 0.57 | 0.50–0.67 | ||
Bold p-values indicate statistical signficance (p < 0.05)
*Missing's where excluded from analyses when less than 5%
**Abbreviations: BMI indicates body mass index; ASA score indicates American Association of Anaesthesiologist; type of hospital, tertiary centre indicates hospitals with the highest expertise on oncological surgery
£ Histopathology of the liver on the basis of pathological examination in millimetre, other including: fibrosis, cirrhosis or sinusoidal dilatation