Table 3.

Multilevel logistic regression model nested for year for perioperative outcomes for patients with colorectal liver metastases who underwent a minor liver resection between 2014 and 2021 in the Netherlands

Factor	Univariable				Multivariable
	N	OR	95% CI	p-value	aOR	95% CI	p-value
Blood loss in ml				< 0.001			< 0.001
Median + IQR	300 (100–600)	0.99	(0.98–0.99)		0.99	0.99–0.99
Missing	221
Bile leakage				0.89
No	2621	1
Yes	41	1.04	0.55–1.94
Missing	14
Intra-abdominal infection				0.003			0.57
No	2443	1			1
Yes	51	0.40	0.21–0.72		1.13	0.74–1.73
Missing	182
Surgical site infection				0.19
No	2355	1
Yes	144	0.80	0.56–1.12
Missing	177
Pneumonia				0.009			0.89
No	2393	1			1
Yes	108	0.59	0.39–0.87		0.97	0.02–1.56
Missing	175
Cardiac complication				0.01			0.009
No	2600	1			1
Yes	57	0.45	0.24–0.82		0.29	0.10–0.70
Missing	19
Overall–30-day morbidity				0.20
No	2262	1
Yes	414	0.87	0.70–1.07
Missing	0
30-day major morbidity				0.13
No	2457	1
Yes	219	0.81	0.61–1.06
Missing
30-day mortality				0.61
No	2631	1
Yes	16	1.28	0.47–3.61
Missing	29
Length of stay				< 0.001			< 0.001
Median + IQR	5 (3.00–7.00)	0.94	0.92–0.95		0.97	0.96–0.99
Missing	33
ICU admission				< 0.001			0.005
No	2254	1			1
Yes	375	0.47	0.37–0.59		0.66	0.50–0.89
Missing	47
Resection margins				0.74
R0	2403	1
R1	220	1.03	0.78–1.35	0.82
R2	17	0.69	0.25–1.81	0.46
Missing	36