Table 2.
Comparative MICs (mg/L) range for CZA and AZA against 67 XDR/PDR P. aeruginosa positive for OXA gene alone and one or more additional β-lactamase genes.
| Group (n) | MICs (mg/L) range for | |
|---|---|---|
| CZA | AZA | |
| OXA-1 + OXA-50 + IMP-45 (2) | >64 | 2–16 |
| OXA-1 + OXA-488 + OXA-573 + VIM-1 + IMP-45 (1) | >64 | 2 |
| OXA-7 + OXA-50 + OXA-101 (1) | 4 | 8 |
| OXA-10 + OXA-50 + VIM-2 (1) | >64 | 8 |
| OXA-17 + OXA-129 + OXA-488 (2) | 32–64 | 32–64 |
| OXA-50 (5) | 4–64 | 4–32 |
| OXA-50 + OXA-101 + OXA-573 (1) | 64 | 64 |
| OXA-50 + OXA-246 + PEDO-3 (1) | 64 | 64 |
| OXA-50 + OXA-573 (2) | 8–16 | 16–32 |
| OXA-101 + OXA-246 + OXA-573 + OXA-846 (1) | 64 | 64 |
| OXA-101 + OXA-488 + OXA-573 (1) | 8 | 16 |
| OXA-101 + OXA-573 + OXA-850 + THIN-B (1) | 16 | 64 |
| OXA-101 + OXA-573 + OXA-850 (1) | 16 | 32 |
| OXA-101 + OXA-850 (22) | 8–>64 | 16–64 |
| OXA-101 + OXA-850 + IND-6 (8) | >64 | >64 |
| OXA-101 + OXA-850 + SLB-1 (1) | 64 | >64 |
| OXA-129 + OXA-488 (1) | 64 | 64 |
| OXA-246 + OXA-486 + OXA-573 + KPC-2 (3) | 8–16 | 8–16 |
| OXA-246 + OXA-573 + OXA-846 (2) | 64–>64 | 64–>64 |
| OXA-488 + OXA-573 (1) | 4 | 16 |
| OXA-488 (2) | 8 | 16 |
| OXA-573 + OXA-846 (1) | 16 | 32 |
| OXA-846 (2) | 4–16 | 8–32 |
| OXA-850 (4) | 8–64 | 8–64 |