Table 3A.

Probability of target attainment (PTA) and cumulative fraction of response (CFR) of CZA/AZA against bloodstream infections (BSIs) caused by XDR/PDR P. aeruginosa.

Antibiotics	Dosing regimens	PTA of different MICs										CFR (%)
		0.25	0.5	1	2	4	8	16	32	64	>64
CZA	2.5g q8h	100	100	100	100	100	100	100	100	88.6	0	71.36
	2.5g q6h	100	100	100	100	100	100	100	100	100	5.48	75.72
	4g q8h	100	100	100	100	100	100	100	100	100	2.78	75.08
	4g q6h	100	100	100	100	100	100	100	100	100	88.85	95.63
	1.25g (0.5h) +1.25g (2h) q8h	100	100	100	100	100	100	100	100	100	93.21	96.67
	1.25g (0.5h) +1.25g (2h) q6h	100	100	100	100	100	100	100	100	100	96.05	97.35
	0.675g (0.5h) +0.675g (2h) q8h	100	100	100	100	100	100	100	100	100	80.34	93.60
	0.675g (0.5h) +0.675g (2h) q6h	100	100	100	100	100	100	100	100	100	80.03	93.53
AZA	2.5g q8h	100	100	100	100	100	100	100	100	89.49	0	71.59
	2.5g q6h	100	100	100	100	100	100	100	100	100	75.75	92.50
	4g q8h	100	100	100	100	100	100	100	100	100	14.15	77.79
	4g q6h	100	100	100	100	100	100	100	100	100	91.78	96.36
	1.25g (0.5h) +1.25g (2h) q8h	100	100	100	100	100	100	100	100	100	94.35	96.95
	1.25g (0.5h) +1.25g (2h) q6h	100	100	100	100	100	100	100	100	100	99.77	98.25
	0.675g (0.5h) +0.675g (2h) q8h	100	100	100	100	100	100	100	100	93.77	7.43	74.51
	0.675g (0.5h) +0.675g (2h) q6h	100	100	100	100	100	100	100	100	99.83	14.67	77.87