Table 3B.

Probability of target attainment (PTA) and cumulative fraction of response (CFR) of CZA/AZA against lower respiratory tract infections (LRTIs) caused by XDR/PDR P. aeruginosa.

Antibiotics	Dosing regimens	PTA of different MICs										CFR (%)
		0.25	0.5	1	2	4	8	16	32	64	>64
CZA	2.5g q8h	100	100	100	100	100	100	12.31	0	0	0	19.38
	2.5g q6h	100	100	100	100	100	100	100	0	0	0	31.16
	4g q8h	100	100	100	100	100	100	100	0	0	0	31.16
	4g q6h	100	100	100	100	100	100	100	0.13	0	0	44.61
	1.25g (0.5h) +1.25g (2h) q8h	100	100	100	100	100	100	100	100	40.85	0	58.53
	1.25g (0.5h) +1.25g (2h) q6h	100	100	100	100	100	100	100	100	45.54	0	59.79
	2g (0.5h) +2g (2h) q8h	100	100	100	100	100	100	100	100	100	41.33	84.29
	2g (0.5h) +2g (2h) q6h	100	100	100	100	100	100	100	100	100	46.32	85.48
AZA	2.5g q8h	100	100	100	100	100	100	31.95	0	0	0	23.68
	2.5g q6h	100	100	100	100	100	100	100	0	0	0	32.82
	4g q8h	100	100	100	100	100	100	100	0.96	0	0	33.00
	4g q6h	100	100	100	100	100	100	100	99.72	0	0	52.16
	1.25g (0.5h) +1.25g (2h) q8h	100	100	100	100	100	100	100	89.14	0	0	50.11
	1.25g (0.5h) +1.25g (2h) q6h	100	100	100	100	100	100	100	98.66	0	0	51.96
	2g (0.5h) +2g (2h) q8h	100	100	100	100	100	100	100	100	90.95	0	84.78
	2g (0.5h) +2g (2h) q6h	100	100	100	100	100	100	100	100	98.60	0	87.51