Table 3.
Association of biomarkers with 28-day mortality in the derivation cohort.
| Biomarker (log10) | Unadjusted | Baseline-adjusteda | Baseline + organ failure-adjustedb | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | OR | 95% CI | P value | |
| IL-1R2 | 33.4 | 5.8–192.8 | <0.001 | 43.0 | 8.2–224.9 | <0.001 | 210.8 | 13.4–3,381 | <0.001 |
| CRP | 2.7 | 0.3–24.9 | 0.37 | 3.3 | 0.4–29.4 | 0.3 | 2.0 | 0.2–19.8 | 0.57 |
| PCT | 80.4 | 2.5–2565.4 | 0.01 | 72.4 | 0.8–6964.8 | 0.07 | 72.3 | 0.5–9,703 | 0.09 |
| sTREM-1 | 3.5 | 1.0–12.2 | 0.06 | 2.9 | 0.9–9.5 | 0.09 | 2.7 | 0.9–8.7 | 0.09 |
| S100A9 | 4.2 | 0.4–40.8 | 0.22 | 6.1 | 0.5–71.9 | 0.15 | 5.6 | 0.5–66.1 | 0.17 |
| Calprotectin | 2.8 | 0.6–11.9 | 0.17 | 3.1 | 0.7–13.9 | 0.14 | 2.3 | 0.5–10.5 | 0.27 |
a
Adjusted for age, sex, and Charlson Comorbidity Index.
b
Adjusted for age, sex, Charlson Comorbidity Index, and organ failure score.