Table 5.

KEGG-enriched molecular pathway with identified metabolites.

No.	Pathway name	Match status	Matched metabolites	p-value	Impact
1	Arginine and proline metabolism	4/38	L-Arginine, creatine, L-proline, and L-ornithine	0.0009	0.25841
2	Glycine, serine, and threonine metabolism	3/33	Choline, betaine, and creatine	0.0068	0.05034
3	Arginine biosynthesis	2/14	L-Arginine and L-ornithine	0.0119	0.13705
4	Aminoacyl-tRNA biosynthesis	3/48	L-Histidine, L-arginine, and L-proline	0.0191	0.00000
5	beta-Alanine metabolism	2/21	Uracil and L-histidine	0.0260	0.00000
6	Glutathione metabolism	2/28	5-Oxoproline and L-ornithine	0.0445	0.00709
7	Glycerophospholipid metabolism	2/36	Choline and acetylcholine	0.0700	0.02582
8	Histidine metabolism	1/16	L-histidine	0.1799	0.22131
9	Purine metabolism	2/65	Hypoxanthine and urate	0.1878	0.01651
10	Pantothenate and CoA biosynthesis	1/19	Uracil	0.2100	0.00000
11	Sphingolipid metabolism	1/21	Sphingosine 1-phosphate	0.2295	0.02434
12	Lysine degradation	1/25	L-pipecolic acid	0.2671	0.00000
13	Porphyrin and chlorophyll metabolism	1/30	Bilirubin	0.3117	0.05288
14	Biosynthesis of unsaturated fatty acids	1/36	Arachidonate	0.3618	0.00000
15	Arachidonic acid metabolism	1/36	Arachidonate	0.3618	0.3135
16	Fatty acid degradation	1/39	L-Palmitoylcarnitine	0.3856	0.00000
17	Pyrimidine metabolism	1/39	Uracil	0.3856	0.0743
18	Tryptophan metabolism	1/41	Indole-3-acetate	0.4009	0.00000
19	Steroid hormone biosynthesis	1/85	Cortisol	0.6597	0.02729