Table 1. Eligibility criteria.

Inclusion criteria
Generally healthy male or female aged 18 to 60 years old as assessed by a medical doctor
Thai, Burmese or Karen ethnicity
Living in Mae Sot city for the last 12 months
Able to tolerate direct mosquito exposure
Exclusion criteria
History of travel in a rural area ( i.e., where participant may be exposed Anopheles bites) in the last 12 months, or plan to do so during the study
Medication or condition deemed to interfere with the outcome measure or increase the risk of an adverse reaction to the study procedures (hypersensitivity to mosquito bites, atopy, systemic mastocytosis, immunodeficiencies, Epstein-Barr virus-associated lymphoproliferative disease, and longue-course oral treatment with a steroidal anti-inflammatory drug)
Moderate and severe anaemia (haemoglobin concentration less than 110 g/L of blood)
Pregnancy
Breastfeeding