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. 2023 Jun 6;27(14):2032–2044. doi: 10.1111/jcmm.17799

FIGURE 1.

FIGURE 1

The level of TS in LUAD and multiple other solid malignancies is significantly upregulated and correlated with decreased disease‐free survival (DFS) and overall survival (OS). (A), Thymidylate synthetase (TYMS or TS) mRNA expression in multiple cancer types. (B), Kaplan–Meier survival analysis comparing high and low TS expression in both the pan‐cancer cohort and the lung adenocarcinoma (LUAD) cohort in GEPIA. (C), The protein level of TS in LUAD tissues and adjacent normal lungs. (D), The metabolic pathways upregulated in gefitinib‐resistant datasets (GSE112274 and GSE114647) with high TS expression, displayed with gene set enrichment analysis (GSEA) using GSEA software. *p < 0.05.