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. 2023 May 31;27(14):1959–1974. doi: 10.1111/jcmm.17787

TABLE 5.

Target molecule docking results for candidate core active constituents.

Compound name Affinity (kcal /mol)
AKT1 CAV1 DPP4 IL6 INSR MAPK8 MMP9 PPARG SLC2A4 Mean
β‐Sitosterol −7.3 −5.0 −6.4 −5.0 −6.7 −5.2 −5.2 −7.7 −6.6 −6.1
Diosgenin −9.7 −7.8 −9.0 −7.0 −9.5 −10.4 −8.4 −8.9 −8.4 −8.8
Formononetin −8.1 −6.7 −8.2 −6.3 −7.5 −6.5 −7.6 −6.8 −8.3 −7.3
Kaempferol −7.8 −6.3 −7.8 −6.6 −7.7 −8.4 −8.0 −6.9 −8.9 −7.6
Luteolin −8.0 −6.0 −8.7 −7.7 −7.9 −7.7 −8.1 −7.2 −8.6 −7.8
Quercetin −8.2 −5.9 −7.8 −6.9 −7.4 −8.5 −8.1 −7.1 −8.6 −7.6
Mean −7.6 −5.8 −7.5 −6.2 −7.2 −7.2 −7.1 −7.0 −7.6
Metformin −5.1 −3.7 −5.0 −4.8 −5.1 −4.7 −5.3 −5.0 −4.7 −4.8