TABLE 5.
Compound name | Affinity (kcal /mol) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
AKT1 | CAV1 | DPP4 | IL6 | INSR | MAPK8 | MMP9 | PPARG | SLC2A4 | Mean | |
β‐Sitosterol | −7.3 | −5.0 | −6.4 | −5.0 | −6.7 | −5.2 | −5.2 | −7.7 | −6.6 | −6.1 |
Diosgenin | −9.7 | −7.8 | −9.0 | −7.0 | −9.5 | −10.4 | −8.4 | −8.9 | −8.4 | −8.8 |
Formononetin | −8.1 | −6.7 | −8.2 | −6.3 | −7.5 | −6.5 | −7.6 | −6.8 | −8.3 | −7.3 |
Kaempferol | −7.8 | −6.3 | −7.8 | −6.6 | −7.7 | −8.4 | −8.0 | −6.9 | −8.9 | −7.6 |
Luteolin | −8.0 | −6.0 | −8.7 | −7.7 | −7.9 | −7.7 | −8.1 | −7.2 | −8.6 | −7.8 |
Quercetin | −8.2 | −5.9 | −7.8 | −6.9 | −7.4 | −8.5 | −8.1 | −7.1 | −8.6 | −7.6 |
Mean | −7.6 | −5.8 | −7.5 | −6.2 | −7.2 | −7.2 | −7.1 | −7.0 | −7.6 | |
Metformin | −5.1 | −3.7 | −5.0 | −4.8 | −5.1 | −4.7 | −5.3 | −5.0 | −4.7 | −4.8 |