TABLE 6.

ADMET profiling of compounds.

Compounds	β‐Sitosterol	Diosgenin	Formononetin	Kaempferol	Luteolin	Quercetin
GI absorption	High	High	High	High	High	High
BBB permeant	No	Yes	Yes	No	No	No
P‐gp substrate	No	No	No	No	No	No
Human oral abs	High	High	High	Media	Media	Media
CYP1A2 inhibitor	No	No	Yes	Yes	Yes	Yes
CYP2C19 inhibitor	No	No	No	No	No	No
CYP2D6 inhibitor	No	No	Yes	Yes	Yes	Yes
CYP2C9 inhibitor	No	No	No	No	No	No
Predicted LD50	890 mg/kg	8000 mg/kg	2500 mg/kg	3919 mg/kg	3919 mg/kg	159 mg/kg
Toxicity
Reverse mutation Ames test	Non‐Toxic	Non‐Toxic	Non‐Toxic	Non‐Toxic	Non‐Toxic	Non‐Toxic
Hepatotoxicity	Inactive	Inactive	Inactive	Inactive	Inactive	Inactive
Carcinogens	Inactive	Inactive	Active(0.50)	Inactive	Active(0.69)	Active(0.69)
Mutagenicity	Inactive	Inactive	Inactive	Inactive	Active(0.52)	Active(0.52)
Cytotoxicity	Inactive	Inactive	Inactive	Inactive	Inactive	Inactive

Abbreviations: BBB, blood–brain barrier; GI, gastrointestinal; Oral abs, oral absorption.