Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 29;11:1164811. doi: 10.3389/fcell.2023.1164811

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Kim, Kim, Kim, Li and Jung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic diagram of the strategies for enamel regeneration. Suitable sources of dental epithelial cells for enamel regeneration to repair enamel damage are expanded in the culture to generate a sufficient number of cells using either 2D or 3D culture systems. Dental epithelial cells were differentiated upon modulation of the signaling pathway in the 2D monolayer culture system. Dental epithelial cells derived from hiPSCs were cultured in a suspension to form spheroids. In this study, ameloblast organoid derived from hiPSCs (hAO) were differentiated upon Noggin–BMP modulation using the 3D culture system after 40 days and recombined with the mouse dental mesenchyme.