Table 4.
Oncological outcomes in the intention-to-treat population.
| MIDP group (n = 131)a | ODP group (n = 127)a | p-value | |
|---|---|---|---|
| Lost to follow-up | 2 (1.5) | 2 (1.6) | 0.96 |
| Survival ratesb | |||
| One-year survival | 96 (76.8) | 88 (72.1) | 0.40 |
| Two-year survival | 41 (45.6) | 42 (48.3) | 0.72 |
| Deceased during follow-up | 51 (39.5) | 49 (39.2) | 0.96 |
| Death cause during follow-up | 0.12 | ||
| Due to tumor-related causes | 37 (72.5) | 43 (87.8) | |
| Other causes | 9 (17.6) | 5 (10.2) | |
| Unknown cause | 5 (9.8) | 1 (2.0) | |
| Recurrence or progressionc | 58 (44.3) | 55 (43.3) | 0.98 |
| Local | 7 (12.1) | 7 (12.7) | |
| Distant | 43 (74.1) | 41 (74.5) | |
| Local and distant | 8 (13.8) | 7 (12.7) | |
| Intraperitoneal recurrence | 53 (40.5) | 48 (37.8) | 0.45 |
| Recurrence free survival—months | 9.0 (7.6–10.4) | 8.0 (5.5–10.5) | 0.10 |
| Adjuvant therapy | 0.85 | ||
| Adjuvant chemotherapy | 78 (59.5) | 73 (57.5) | |
| Adjuvant radiotherapy | 1 (0.8) | 0 (0.0) | |
| Adjuvant chemoradiotherapy | 7 (5.3) | 9 (7.1) | |
| Time to adjuvant therapy—days | 57 (51.5–62.5) | 57 (50.6–63.4) | 0.37 |
| Tumor markers at one-year follow-up | |||
| CEA—ng/mL | 3.0 (2.0–5.3) | 2.7 (1.5–5.4) | 0.46 |
| CA 19–9—u/mL | 26.5 (9.0–84.0) | 20.0 (5.3–137.0) | 0.44 |
Categorical data are reported in numbers and frequencies.
Normally distributed continuous data are reported in mean (SD).
Non-normally distributed continuous data are reported in median (IQR). Time-to-event data are reported in median and 95% confidence interval.
MIDP, Minimally invasive distal pancreatectomy; ODP, Open distal pancreatectomy; CEA, Carcinoembryonic antigen; CA, Carbohydrate antigen; mL, Millilitre.
Data were available for 254 patients (129 MIDP and 125 ODP), four patients were lost to follow-up.
In the intention-to-treat population, one-year survival was available for 247 patients (125 MIDP, 122 ODP), two-year survival was available in 177 patients (90 MIDP, 87 ODP).
Intraperitoneal progression or recurrence occurred in 33.6% in the MIDP group and in 33.1% in the ODP group (p = 0.93).