Table 1.
Baseline characteristics of study sample by cognitive trajectory class membership (N = 8198).
| Cognitive class | |||||
|---|---|---|---|---|---|
|
| |||||
| 1=Low(N=1115) | 2=Medium(N=3453) | 3=High(N =3630) | Total (N=8198) | p value | |
| Age (in Years) | |||||
| Mean (SD) | 68.3 (4.4) | 67.8 (3.6) | 67.0 (2.8) | 67.5 (3.4) | <0.00011 |
| Median | 66.0 | 66.0 | 66.0 | 66.0 | |
| Q1, Q3 | 65.0, 71.0 | 65.0, 70.0 | 65.0, 68.0 | 65.0, 69.0 | |
| Sex [n (%)] | <0.00012 | ||||
| 1 = Male | 494 (44.3%) | 1644 (47.6%) | 1335 (36.8%) | 3473 (42.4%) | |
| 2 = Female | 621 (55.7%) | 1809 (52.4%) | 2295 (63.2%) | 4725 (57.6%) | |
| Race [n (%)] | <0.00012 | ||||
| Other | 453 (40.6%) | 526 (15.2%) | 211 (5.8%) | 1190 (14.5%) | |
| Whites | 662 (59.4%) | 2927 (84.8%) | 3419 (94.2%) | 7008 (85.5%) | |
| Region of United States [n (%)] | <0.00012 | ||||
| Midwest | 217 (19.5%) | 866 (25.1%) | 1031 (28.4%) | 2114 (25.8%) | |
| Northeast | 145 (13.0%) | 584 (16.9%) | 622 (17.1%) | 1351 (16.5%) | |
| South | 598 (53.6%) | 1377 (39.9%) | 1265 (34.8%) | 3240 (39.5%) | |
| West | 155 (13.9%) | 626 (18.1%) | 712 (19.6%) | 1493 (18.2%) | |
| Education (in Years) | <0.00011 | ||||
| Mean (SD) | 9.0 (3.8) | 12.0 (2.8) | 13.8 (2.3) | 12.4 (3.2) | |
| Median | 10.0 | 12.0 | 13.0 | 12.0 | |
| Q1, Q3 | 7.0, 12.0 | 11.0, 13.0 | 12.0, 16.0 | 12.0, 14.0 | |
| Neighborhood Socioeconomic Status | <0.00011 | ||||
| First quartile | 555 (48.8%) | 915 (26.5%) | 578 (15.9%) | 2048 (25.0%) | |
| Second quartile | 259 (23.2%) | 940 (27.2%) | 853 (23.5%) | 2052 (25.0%) | |
| Third quartile | 192 (17.2%) | 879 (25.5%) | 977 (26.9%) | 2248 (25.0%) | |
| Fourth quartile | 109 (9.8%) | 719 (20.8%) | 1222 (33.7%) | 2050 (25.0%) | |
| Genetic Risk Score | 0.00011 | ||||
| Mean (SD) | 9.8 (2.1) | 9.6 (2.0) | 9.5 (2.0) | 9.6 (2.0) | |
| Median | 9.3 | 9.3 | 9.2 | 9.3 | |
| Q1, Q3 | 8.1, 11.5 | 8.1, 11.4 | 8.1, 10.4 | 8.1, 11.4 | |
| APOE ɛ4 [n (%)] | <0.00012 | ||||
| No | 737 (66.1%) | 2477 (71.7%) | 2793 (76.9%) | 6007 (73.3%) | |
| Yes | 378 (33.9%) | 976 (28.3%) | 837 (23.1%) | 2191 (26.7%) | |
| Any heart condition [n (%)] | <0.00012 | ||||
| No | 808 (72.5%) | 2583 (74.8%) | 2892 (79.7%) | 6283 (76.6%) | |
| Yes | 307 (27.5%) | 870 (25.2%) | 738 (20.3%) | 1915 (23.4%) | |
| Diabetes [n (%)] | <0.00012 | ||||
| No | 832 (74.6%) | 2924 (84.7%) | 3313 (91.3%) | 7069 (86.2%) | |
| Yes | 283 (25.4%) | 529 (15.3%) | 317 (8.7%) | 1129 (13.8%) | |
| Hypertension [n (%)] | <0.00012 | ||||
| No | 473 (42.4%) | 1689 (48.9%) | 1987 (54.7%) | 4149 (50.6%) | |
| Yes | 642 (57.6%) | 1764 (51.1%) | 1643 (45.3%) | 4049 (49.4%) | |
| Stroke [n (%)] | <0.00011 | ||||
| No | 1020 (91.5%) | 3319 (96.1%) | 3570 (98.3%) | 7909 (96.5%) | |
| Yes | 95 (8.5%) | 134 (3.9%) | 60 (1.7%) | 289 (3.5%) | |
| HRS TICS Score (Baseline) | <0.00011 | ||||
| Mean (SD) | 16.4 (4.1) | 22.2 (3.0) | 26.6 (2.9) | 23.3 (4.6) | |
| Median | 16.0 | 22.0 | 26.0 | 24.0 | |
| Q1, Q3 | 14.0, 19.0 | 20.0, 24.0 | 25.0, 28.0 | 21.0, 26.0 | |
1
Kruskal Wallis.
2
Chi-Square.
Note. APOE ε4: Apolipoprotein E, allele ε4. HRS TICS: Health and Retirement Study version of the Telephone Interview for Cognitive Status. NSES: Neighborhood socioeconomic status. Q1: First quartile. Q3: Third quartile. SD: Standard deviation.