Table 2.

Demographic, genetic, socioeconomic, regional, and time-varying predictors of cognitive trajectory class (n = 8,198).

Variable	Cognitive Trajectory Class Odds Ratio (95% Confidence Limits)
	Low	Medium	High
Demographics
Age in years	1.0 (REFERENCE)	0.94 (0.91–0.96)	0.83 (0.81–0.86)
Sex	1.0 (REFERENCE)	0.98 (0.81–1.18)	2.42 (1.96–2.99)
Female [Reference: Male]
Race	1.0 (REFERENCE)	4.19 (3.35–5.25)	18.50(13.63–25.13)
[White [Reference: Othera]
Education (Years)	1.0 (REFERENCE)	1.41 (1.36–1.46)	2.09 (1.99–2.18)
Genetic Factors
APOE ɛ4 [reference: no APOE ɛ4]	1.0 (REFERENCE)	0.68 (0.56–0.83)	0.40 (0.32–0.50)
Genetic Risk Score	1.0 (REFERENCE)	1.01 (0.96–1.06)	0.98 (0.93–1.03)
Socioeconomic Factors
Neighborhood socioeconomic status (NSES)
Q2 vs Q1	1.0 (REFERENCE)	1.07 (0.85–1.36)	1.80 (0.89–1.55)
Q3 vs Q1	1.0 (REFERENCE)	1.32 (0.99–1.73)	1.45 (1.07–1.97)
Q4 vs Q1	1.0 (REFERENCE)	1.06 (0.77–1.45)	1.57 (1.12–2.19)
Regional Factors
Region of United States
West [Reference: South]	1.0 (REFERENCE)	1.21 (0.92–1.60)	1.24 (0.93–1.68)
Mid-west [Reference: South]	1.0 (REFERENCE)	1.15 (0.90–1.46)	1.51 (1.16–1.96)
North-East [Reference: South]	1.0 (REFERENCE)	1.39 (1.06–1.85)	1.57 (1.16–2.14)
Time-Varying Covariates	β (SD)
Any Heart Condition	−0.28 (0.13)*	−0.28 (0.07)*	−0.29 (0.06)*
Diabetes	−0.64 (0.14)*	−0.67 (0.09)*	−0.48 (0.09)*
Hypertension	−0.76 (0.12)*	−0.47 (0.07)*	−0.09 (0.06)
Stroke	−1.75 (0.21)*	−1.45 (0.14)*	−1.01 (0.13)*

Note. APOE ε4: Apolipoprotein E, allele ε4. b: Beta (regression coefficient). NSES: Neighborhood socioeconomic status. Q1: First quartile. Q2: Second quartile. Q3: Third quartile. Q4: Fourth quartile. SD: Standard deviation.

^aThe “Other” category for race included African Americans, American Indians, Asians, and individuals who did not consider themselves to be part of any of these groups.

^*p < 0.05.