Table 3.
Resistance-Associated mutations/gene(s) in the 56 N. gonorrhoeae isolates from Ghana.
| Gene | AMR-Associated amino acid substitutions | Prevalence N (%) | Antibiotic group(s) |
|---|---|---|---|
| PBP2 | A501T | 8 (14) | Beta-lactams: Penicillins and Cephalosporins |
| G542S | 8 (14) | ||
| F504L | 56 (100) | ||
| A510V | 56 (100) | ||
| A516G | 55 (98) | ||
| P551S | 10 (18) | ||
| PBP1 | L421P | 35 (62.5) | |
| gyrA | S91F | 49 (87.5) | Fluoroquinolones: Ciprofloxacin |
| D95G | 20 (36) | ||
| parC | E91G | 9 (16) | |
| S87R | 7 (12.5) | ||
| mtrR | A39T | 17 (30) | Beta-lactams & Azithromycin |
| G45D | 9 (16) | ||
| penB | G120D | 11 (20) | Beta-lactams and Tetracyclines |
| G120K | 4 (7) | ||
| A121D | 1 (2) | ||
| rpsJ | V57M | 56 (100) | Tetracyclines |
| rpld | G70D | 4 (7) | Macrolides |
| macB | Not relevant | 13 (23) | |
| blaTEM | Not relevant | 52(92.8) | Beta-lactams |
| tetM | Not relevant | 52(92.8) | Tetracyclines |