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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: Trends Cancer. 2023 Apr 25;9(7):591–601. doi: 10.1016/j.trecan.2023.03.008

Figure 1. Genomic Barcoding.

Figure 1

The general process and outcomes of genomic barcoding are similar among technologies. A) Barcodes are delivered into cells by viral transduction and cells which successfully integrate a barcode are isolated via FACS or antibiotic selection. B) Investigations using barcoded cells measure clonal frequencies and longitudinal clonal dynamics by high-resolution genomic sequencing of the barcode ensemble. Clonally-resolved transcriptome data is measured by scRNA-Seq. C) Some barcoding techniques allow for clone-specific activation of fluorescent reporter genes, allowing for isolation of particular clones and further live cell or molecular characterization.