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. 2023 May 30;9(5):764. doi: 10.18063/ijb.764

Table 2. Applications of 4D-printed representative implants.

Applications Ink compositions Fabrication methods Stimuli Deformation principle References
Bone repair Chitosan (CS) reinforced poly-lactic-acid (PLA) Fused filament fabricated (FFF) Temperature Shape memory effect of SMPs [129]
Poly (D,L-lactide-co-trimethylene carbonate) Extrusion-based printing Temperature Shape memory effect of SMPs [130]
Poly (ε-caprolactone)-diacrylates (PCLDA) DLP Solvent, temperature Anisotropic swelling behavior and shape memory effect of SMP [108]
PLA∕Fe,O4 FDM Temperature, magnetic field Shape memory effect of SMPs, and addition of magnetic particles [128,116]
Vascular stents Polyurethane FDM Temperature Shape memory effect of SMPs [104]
PLA FDM Temperature Shape memory effect of SMPs [60]
Poly (glycerol dodecanoate) acrylate (PGDA) Extrusion-based printing Temperature Shape memory effect of SMPs [UI]
s-PCL UV light-assisted 3D printing Temperature Shape memory effect of SMPs [135]
PLA FDM Temperature Shape memory effect of SMPs [30]
Vascular repair devices Urethane diacrylate and semi-crystalline polycaprolactone (PCL) DIW Temperature Shape memory effect of SMPs [136]
Cardiac defect PLA-MNCs FDM Temperature, magnetic field Shape memory effect of SMPs, and addition of magnetic particles [139]
PLA-Fe3O4 nanoparticles FDM Temperature, magnetic field Shape memory effect of SMPs, and addition of magnetic particles [112]
Polyethylene glycol (PEG)∕PLA FDM Temperature Shape memory effect of SMPs [140]
Cardiac patches A shape memory polymer and graphene DLP Temperature, nearinfrared (NIR) light Shape memory effect of SMPs, photothermal conversion capacity of graphene [HO]
Tracheal stent Bi-Iayered Sil-MA hydrogels DLP Solvent Anisotropic swelling behavior [76]
Polypropylene glycol/polycaprolactone triblocks DLP Temperature Shape memory effect of SMPs [144]
Methacrylated polycaprolactone SLA Temperature Shape memory effect of SMPs [145]
PLA∕Fe,o4 FDM Magnetic field, infrared light Addition of magnetic particles, photothermal capacity of infrared light [146]
PLA∕Fe,O4 FDM Magnetic field Addition of magnetic particles [147]
PLA/PCL DIW Temperature Shape memory effect of SMPs [148]
Brain model SMP and graphene Extrusion-based printing NIR Photothermal conversion capacity of graphene [150]
Nerve regeneration Reduced GO, mesoporous silica, and a thin carbon layer DLP Magnetoelectric Magnetoelectric conversion of materials [152]
Soybean oil epoxidized acrylate (SOEA) SLA Solvent Internal-stress-induced transformation [33]
Skeletal muscle mimetic tissue Polyvinyl alcohol (PVA), PCL and PLA coating, SOEA coating FDM Temperature Shape memory effect of SMPs [31]
Gelatin methacryloyl (GelMA), gelatin Electrically assisted extrusion-based printing Solvent Anisotropic swelling behavior [149]
Intestine repair Acrylamide-acrylic acid/cellulose nanocrystal Extrusion-based printing UV light, solvent Anisotropic shrinkage and swelling behavior [85]
Orbital stent PTU, gold nanoparticles, nano-hydroxyapatite Extrusion-based printing Temperature Shape memory effect of SMPs [153]
Drug delivery AAc, N-isopropylacrylamide, PVP Femtosecond laser direct writing pH Different swelling behavior in alkaline and acid solutions [114]
Zein gel Extrusion-based printing Solvent Porosity influenced by hydrophobic attraction [157]
Poly (N-isopropylacrylamide) (PNIPAM) Extrusion-based printing Temperature Thermo-responsive characteristics of material [155]