Fig. 1.

Illustration of the experimental design and verification of PBMC engraftment in BRGSF mice. A Schematic representations of the experimental design. B Representative images of flow cytometry for mouse (m) CD45⁺, human (h) CD45⁺, hCD3⁺, hCD4⁺, hCD8⁺, and hCD19⁺ cells in blood, bone marrow, and spleen of BRGSF mice. HC and patient refer to mice injected with PBMCs from healthy control and patients (n = 3/group), respectively