Table 1.
Baseline and demographic characteristics of participants with and without hyperuricemia in NHANES, 2001–2018
| Variables | Normal uric acid (unweighted n = 34,556) |
Hyperuricemia (unweighted n = 8999) |
P value |
|---|---|---|---|
| Weighted, n (%) | 164,134,832 (80.4) | 40,044,228 (19.6) | |
| Age (mean [SE])a | 46.48 (0.20) | 51.04 (0.28) | < 0.001 |
| Age groups (%) | < 0.001 | ||
| 20–39 | 11,949 (37.8) | 2214 (30) | |
| 40–59 | 11,713 (39.1) | 2660 (35.2) | |
| 60–79 | 8807 (19.5) | 3159 (27.5) | |
| ≥ 80 | 2087 (3.6) | 966 (7.2) | |
| Gender (%) | < 0.001 | ||
| Men | 16,616 (46.9) | 4987 (57.1) | |
| Women | 17,940 (53.1) | 4012 (42.9) | |
| Race (%) | < 0.001 | ||
| Mexican American | 6209 (5.9) | 1050 (8.8) | |
| Other Hispanic | 3109 (4.2) | 585 (5.7) | |
| Non-Hispanic White | 15,231 (70.3) | 4243 (68.2) | |
| Non-Hispanic Black | 6655 (12.4) | 2244 (10.2) | |
| Other race | 3352 (7.2) | 877 (7.0) | |
| Education level (%) | < 0.001 | ||
| Less than 9th grade | 4044 (5.8) | 997 (5.9) | |
| 9–11th grade | 4927 (10.7) | 1311 (11.0) | |
| High school graduate | 7874 (23.3) | 2232 (26.1) | |
| College or AA degree | 9853 (30.8) | 2701 (33.1) | |
| College graduate or above | 7817 (29.4) | 1746 (23.8) | |
| Citizenship status (%) | < 0.001 | ||
| Citizen by birth or naturalization | 29,196 (90.3) | 8192 (93.9) | |
| Not a citizen of the US | 5291 (9.6) | 797 (6.0) | |
| Marital status (%) | |||
| Married/living with partner | 21,000 (64.5) | 5111 (60.9) | < 0.001 |
| Widowed/divorced/separated | 7347 (17.7) | 2471 (22.3) | |
| Never married | 6190 (17.8) | 1413 (16.7) | |
| Insurance status (%) | < 0.001 | ||
| Yes | 26,830 (81.7) | 7464 (84.2) | |
| No | 7621 (18.0) | 1507 (15.5) | |
| BMI (%) | < 0.001 | ||
| < 18.5 | 631 (1.9) | 44 (0.4) | |
| 18.5–24.9 | 10,690 (32.6) | 1199 (12.6) | |
| 25–29.9 | 11,742 (33.6) | 2721 (30.4) | |
| ≥ 30.0 | 10,948 (30.7) | 4818 (54.7) | |
| Waist circumferencea | 96.45 (0.18) | 107.66 (0.31) | < 0.001 |
| Smoking (%) | 15,546 (45.5) | 4455 (49.0) | < 0.001 |
| Total cholesterol | 5.03 (0.011) | 5.20 (0.017) | < 0.001 |
| Triglycerides | 1.61 (0.013) | 2.12 (0.026) | < 0.001 |
| Hypertension (%) | 10,572 (26.8) | 4910 (48.9) | < 0.001 |
| Diabetes (%) | 3883 (8.1) | 1569 (13.5) | < 0.001 |
| Cancer (%) | 3015 (9.1) | 1085 (11.9) | < 0.001 |
| Stroke (%) | 1127 (2.4) | 561 (4.6) | < 0.001 |
| Heart failure (%) | 790 (1.6) | 681 (5.7) | < 0.001 |
| Coronary artery disease (%) | 1257 (3.0) | 596 (5.5) | < 0.001 |
| Heart disease (combination of CAD, stroke, heart failure) (%) | 2550 (5.8) | 1401 (12.2) | < 0.001 |
CAD coronary artery disease
aData are presented as unweighted n (weighted percentage) for categorical variables and weighted means and standard errors for continuous variables