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. 2023 Jul 12;21:464. doi: 10.1186/s12967-023-04268-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — CHCHD4 attenuates hypoxic PAH. Hemodynamic examination was analyzed after the Normoxia or hypoxia exposure 28th day and then animals sacrificed. A The RVSP of the Normoxia and hypoxia rats with or without AAV-CHCHD4 treatment (n = 9). B Summary data of the right ventricle/(left ventricle + septum) weight ratio (n = 9). C Representative images of RVSP measurements in Normoxia and hypoxia rats with or without AAV-CHCHD4 treatment (n = 9). D H&E staining of pulmonary arteries in lung tissues in indicated animals. E Quantification of ratio of pulmonary arterial medial thickness to total vessel size (media/CSA) in each group (n = 9). F Double immunofluorescence staining of α-SMA (green) and Ki67 (red) in pulmonary arteries of the Normoxia and hypoxia rats with or without AAV-CHCHD4 treatment. G Quantification of Ki67 positive cells in pulmonary arteries (n = 9). Data are shown as the mean ± SEM. P value is showed in each figure