Table 2.
Geometric means of antibody titer (BAU/mL) stratified by age group and measurement week
| September 2021 | December 2021 | February 2022 | September vs. December | December vs. February | |
|---|---|---|---|---|---|
| Geometric mean of antibody titer (BAU/mL) | Hodges-Lehmann estimate [95% CI]& | ||||
| Pfizer or Moderna | |||||
| 18–25 | 780.5 | 295.6 | 1397.8 | 834.0 [346.2,1149.3]*** |
-1064.0 [-820.2, -1288.5]*** |
| 26–35 | 797.1 | 254.0 | 1174.1 |
681.0 [518.9, 852.9]*** |
-981.2 [-831.9, -1130.9]*** |
| 36–45 | 582.4 | 243.2 | 1178.7 |
456.6 [368.4, 548.8]*** |
-1001.5 [-827.7, -1215.1]*** |
| 46–55 | 572.9 | 212.0 | 1766.7 |
442.1 [362.6, 519.8]*** |
-1793.8 [-1564.3, -2039.0]*** |
| 56–65 | 405.6 | 164.7 | 1825.1 |
219.2 [165.6, 278.6]*** |
-1848.8 [-1547.5, -2232.3]*** |
| 66–75 | 219.7 | 108.3 | 1667.1 |
98.2 [80.9, 116.5]*** |
-1633.3 [-1490.6, -1761.9]*** |
| Total | 444.2 | 181.6 | 1552.9 |
239.8 [206.5, 277,3]*** |
-1433.3 [-1355.1, -1510.1]*** |
| Janssen^ | |||||
| 36–45 | 147.5 | 59.4 | 1682.3 |
55.9 [2.8, 272.8]* |
-1800.2 [-947.0, -2295.4]*** |
| 46–55 | 92.7 | 71.9 | 1107.3 |
7.4 [-14.2, 28.8]ns |
-884.1 [-743.7, -1316.1]*** |
| Total | 103.3 | 68.0 | 1213.44 |
14.4 [-1.9, 36.5]ns |
-1026.6 [-802.3, -1454,6]*** |
| AstraZeneca # | |||||
| 56–65 | 90.3 | 48.5 | 1155.0 |
35.6 [21.8, 51.8]*** |
-1165.9 [-1009.2, -1272.2]*** |
| Previous infection | |||||
| 18–25 | 1019.7 | 689.7 | 1659.6 |
310.7 [-101.0, 893.1]ns |
-889.6 [-411.2, -1448.4]*** |
| 26–35 | 890.6 | 549.5 | 1239.4 |
274.6 [-64.2, 779.9]ns |
-595.7 [-238.6, -1005.6]** |
| 36–45 | 910.1 | 650.9 | 1781.0 |
363.5 [-20.7, 864.2]ns |
-984.3 [-519.2, -1490.2]*** |
| 46–55 | 1016.0 | 679.2 | 2162.1 |
417.7 [106.7, 771.2]** |
-1432.3 [-1025.8, -1982.2]*** |
| 56–65 | 1027.7 | 769.8 | 2625.2 |
142.8 [-128.4, 443.6]ns |
-1784.3 [-1333.4, -2334.0]*** |
| 66–75 | 1099.7 | 861.8 | 2985.2 |
150.4 [-185.4, 503.1]ns |
-1712.0 [-1090.0, -2595.9]*** |
| Total | 994.2 | 708.2 | 2022.7 | 263.2 [126.8, 416,5]*** |
-1219.4 [-1015.0, -1432.4]*** |
^birth cohorts 1967, 1968, and 1976
# birth cohorts 1956–1960
& Tested with Mann-Withney U test
* = p < 0.05, ** = p < 0.01, *** = p < 0.001 ns = not significant