Figure 2:

Diurnal plasma ACTH (upper panels) and corticosterone (lower panels) results in female and male rats Before and then During abstinence from opioids in control rats and rats under sleep restricted (SR) conditions vs. ambulatory controls (AC) (Male: N=15-16 per mean/SE for treatment groups; Female: N=14-16 per mean/SE for treatment groups). All statistical symbols are P < 0.05. a, male different from female within Before or During, b, During different from Before within sex. For overall ANOVA and all specific comparisons, see the link to Supplementary Table 2 in the reference list (2).

Figure 2 Alt Text: Opioid abstinence resulted in an increase AM plasma ACTH and corticosterone in male but not female rats regardless of sleep state (left panels).