Table 2.

Role of different kinds of exosome miRNAs in nervous system diseases.

Disease model	miRNA	Source	Research results	Reference
AD	miR-34a	Rat cortical neuron-Exo	miR-34a activated synaptic linkage and proved polygenic AD formation mechanism	[58]
AD	miR-193b	CSF and serum-Exo	Control diseases affected by amyloid precursor protein	[59]
PD	miR-136-3p, miR-433, miR-153, miR-409-3p	CSF-Exo	miRNAs can play a significant role as biomarkers	[60]
PD	miR-34a-5p	Plasma-Exo	miR-34a-5p is helpful in distinguishing healthy people from PD patients and in assessing depression levels	[61]
Stroke	miR-126	EPCs-Exo	Regulate PI3K pathway can effectively reduce cerebral infarction size and promote vascular regeneration	[62]
Stroke	miR-17-92	MSCs-Exo	Restore the function of nerve cells and reduce damage	[63]
Stroke	miR-134	Serum-Exo	Regulate inflammatory factors, infarct size and influence prognosis	[64]
Epilepsy	miR-346 miR-331-3p	Rat forebrain-Exo	Inhibit neurotransmitter transmission	[65]
ALS	miR-494-3p	Astrocyte-Exo	Affect motor neuron function and induce neuron degeneration	[66]
MS	miR-326	CD4 + T cells-Exo	Regulate the immune response	[67]
HD	miR-128 miR-130b-3p	Serum and plasma-Exo	miRNAs are closely related to ageing-related diseases	[68]

AD: Alzheimer’s disease; PD: Parkinson’s disease; ALS: amyotrophic lateral sclerosis; MS: multiple sclerosis; HD: Huntington’s disease; MSCs: mesenchymal stem cells; Exo: exosome; CSF: cerebrospinal fluid; EPCs: endothelial progenitor cells.