Materson 1993.

Study characteristics
Methods	Randomized, double‐blind, placebo‐controlled study for a period of 1 year
Participants	1292 male veterans with resting diastolic blood pressure of 95 mmHg to 109 mmHg
Interventions	Placebo or 1 of the 6 drugs: hydrochlorothiazide 12.5 mg to 50 mg/day; atenolol 25 mg to 100 mg/day; captopril 25 mg to 100 mg/day; clonidine 0.2 mg to 0.6 mg/day; a sustained preparation of diltiazem 120 mg to 360 mg/day or prazosin 4 mg to 20 mg/day
Outcomes	Withdrawals due to adverse effects Duration 1 year
Notes	Morbidity and mortality not reported. Blood pressure not reported at 1 year.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Method not reported.
Allocation concealment (selection bias)	Unclear risk	Method of achieving allocation concealment was not reported.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Blinding maintained.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Blinding of withdrawals due to adverse effects outcome.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Low rate of withdrawals in each arm.
Selective reporting (reporting bias)	Low risk	Withdrawals due to adverse effects reported in each group.
Use of supplemental drugs	Low risk	No supplemental drugs allowed.
Industry sponsorship	Low risk	Veterans administration trial. No industry involvement.