Table 2.

NLS/NES motifs in DTX proteins and observed cellular localization.

Name	Predicted/Verified NLS Motif	Probability	Observed Cellular Localization	References
DTX1	161-RTQRRRRRLRRR-172 379-RKTKKKHLKKSK-390	P [0~1]:0.815 P [0~1]:0.887	Cytoplasmic ≤ nuclear	Yamamoto 2001 [27] Ahmed 2020 [17] Nguyen et al., 2009 [26]
DTX2	No predicted motif(s)	n/a	Cytoplasmic ≤ nuclear	Yamamoto 2001 [27], Ahmed [17] Nguyen et al., 2009 [26]
DTX3	No predicted motif(s)	n/a	Cytoplasmic ≥ nuclear	Scalia at al personal observations Nguyen et al., 2009 [26]
DTX3L	2 NLS + 1 NES reported Despite no predicted motif(s) found in present analysis	n/d	Cytoplasmic > nuclear	Zhang et al., 2015 [31] Nguyen et al., 2009 [26] Wang et al., 2021 [30]
DTX4	378-KTTKKQAKKGK-388	P [0~1]:0.758	TBD	Nguyen et al., 2009 [26]