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. 2023 Jun 25;12(13):1716. doi: 10.3390/cells12131716

Figure 2.

Figure 2

BiKE activates PBMC-derived NK cells towards IL13Rα2-positive gliomas. GBM6 or GBM39 spheroids were co-cultured for 24 h with either NK cells alone (NK Cells) or in combination with sdCD16 (sdCD16) or BiKE (BiKE). Expression levels of IL13Rα2 in both (A) GBM6 and (B) GBM39 are provided. BiKE significantly increased NK activation markers CD25 and CD69 in both (C) GBM6 and (D) GBM39 co-culture conditions. Treatment with BiKE resulted in significantly more killing of tumor cells than sdCD16-treated NK cells, NK cells alone, or controls in both (E) GBM6 and (F) GBM39 co-culture. * = p < 0.05, ** = p < 0.01, and *** = p < 0.001.