Table 2.
Model parameters of costs and utilities: baseline values, ranges, and distributions.
| Variable | Baseline Value (Range) | Reference | Distribution |
|---|---|---|---|
| Drug cost per dosage unit, $ | |||
| Palbociclib (125 mg) | 30.54 (24.43–36.65) | Local database |
Gamma (96.00, 3.14) |
| Ribociclib (200 mg) | 42.00 (33.60–50.40) | Gamma (96.04, 2.29) | |
| Abemaciclib (150 mg) | 12.75 (10.20–15.30) | Gamma (96.04, 7.53) | |
| Letrozole (2.5 mg) | 0.32 (0.26–0.38) | Gamma (96.04, 300.13) | |
| Anastrozole (1 mg) | 0.42 (0.34–0.50) | Gamma (96.04, 228.67) | |
| Supportive care | 274 (219.20–328.80) | [22,23,24,25] | Gamma (96.04, 0.35) |
| Imaging/Surveillance | 176.49 (141.19–211.79) | [22,23,24,25] | Gamma (96.03, 0.54) |
| Laboratory test | 82.59 (66.07–99.11) | [22,23,24,25] | Gamma (96.02, 1.16) |
| End of life care | 9032 (7225–10,838) | [22,23,24,25] | Gamma (96.04, 0.01) |
| AEs cost, $ | |||
| Anemia | 6434 (5147.2–7720.8) | [22,23,24,25] | Gamma (96.04, 0.015) |
| Thrombocytopenia | 3551 (2841.36–4262.04) | [22,23,24,25] | Gamma (96.04, 0.027) |
| Neutropenia | 21,156 (16,924.8–25,387.2) | [22,23,24,25] | Gamma (96.04, 0.005) |
| Leukopenia | 21,156 (16,924.8–25,387.2) | [22,23,24,25] | Gamma (96.04, 0.005) |
| Diarrhea | 7377 (5901.6–8852.4) | [22,23,24,25] | Gamma (96.04, 0.013) |
| Hepatobiliary toxicity | 7516 (6012.8–9019.2) | [22,23,24,25] | Gamma (96.04, 0.012) |
| Fatigue | 6908 (5526.4–8289.6) | [22,23,24,25] | Gamma (96.04, 0.014) |
| Infection | 10,128 (8102.4–12,153.6) | [22,23,24,25] | Gamma (96.04, 0.009) |
| Nausea | 6182 (4945.6–7418.4) | [22,23,24,25] | Gamma (96.04, 0.016) |
| Vomiting | 5246 (4196.8–6295.2) | [22,23,24,25] | Gamma (96.04, 0.018) |
| Pulmonary embolism | 10,036 (8028.8–12,043.2) | [22,23,24,25] | Gamma (96.04, 0.010) |
| Discount rate, % | 3 | [22,23,24,25] | Beta (0.03, 0.97) |
| Body Weight (kg) | 65 (32.5–97.5) | [22,23,24,25] | Gamma (15.37, 0.24) |
| Body surface area (m2) | 1.72 (1.376–2.064) | [22,23,24,25] | Gamma (96.04, 55.84) |
| Utility | |||
| Progression-free state (PR/CR) | 0.8345 (0.6676–1.00) | [24,25] | Beta (0.8345, 0.1655) |
| Progression-free state (SD) | 0.8296 (0.6637–0.9955) | [24,25] | Beta (0.8296, 0.1704) |
| Progression state (PD) | 0.5050 (0.404–0.606) | [24,25] | Beta (0.505, 0.495) |