Figure 6.

Proteolytic cleavages in osteopontin and the thrombin cleavage fragments. Vertical arrows mark site of enzyme cleavage. Asp D: aspartic-acid-rich domain, Ca⁺⁺ BD: calcium-binding domain, heparin BD: heparin-binding domain, RGD: ArgGlyAsp integrin-binding site, SVVYGLR: cryptic integrin-binding site. OPN-FL: full-length OPN, OPN-R: N-terminal fragment generated by thrombin cleavage with C-terminal Arg¹⁶⁸, OPN-CTF: C-terminal fragment generated by thrombin cleavage with N-terminal Ser¹⁶⁹. Created with BioRender.com.