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Receiver-operating characteristic (ROC) curves (dark line) and respective 95% confidence intervals (CI; grey area) for the discrimination of patients with progressive disease (PD) from patients with no progression (stable disease + partial remission) for methylated PTGER4 (A–C) and SHOX2 (D–F) before start of therapy (V1), at time of first radiological staging (VS) and the ratio between both time points (VS/V1).
