NSCLC |
Non-Small Cell Lung Cancer |
PET |
Positron Emission Tomography |
GEO |
Gene Expression Omnibus |
TCGA |
The Cancer Genome Atlas |
MDS |
Multidimensional Scaling |
UMAP |
Uniform Manifold Approximation and Projection |
TP53 |
Tumor Protein 53 |
EGFR |
Epidermal Growth Factor Receptor |
ALK |
Anaplastic Lymphoma Kinase |
MRI |
Magnetic Resonance Imaging |
CT |
Computed Tomography |
FISH |
Fluorescence In Situ Hybridization |
PCR |
Polymerase Chain Reaction |
IHC |
Immunohistochemistry |
TKIs |
Tyrosine Kinase Inhibitors |
OPN |
Osteopontin |
PI3K/AKT/mTOR |
Phosphoinositide 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin |
RET |
Rearranged during Transfection |
JAK-STAT |
Janus Kinase-Signal Transducer and Activator of Transcription |
RAS/MAPK |
Rat Sarcoma/Mitogen-Activated Protein Kinase |
MET |
Mesenchymal Epithelial Transition |
EMT |
Epithelial-Mesenchymal Transition |
HER2 |
Human Epidermal Growth Factor Receptor 2 |
MEK/ERK |
Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase |
BRAF |
B-Raf Proto-Oncogene, Serine/Threonine Kinase |
ROS1 |
ROS Proto-Oncogene 1, Receptor Tyrosine Kinase |
KRAS |
Kirsten Rat Sarcoma Viral Oncogene Homolog |
NTRK |
Neurotrophic Tropomyosin Receptor Kinase |
TME |
Tumor Microenvironment |
ICBs |
Immune Checkpoint Inhibitors |
STK11 |
Serine/Threonine Kinase 11 |
NGS |
Next-Generation Sequencing |
TNM |
Tumor, Node, Metastasis |
FDA |
U.S. Food and Drug Administration |
NIH |
National Institutes of Health |
DNA |
Deoxyribonucleic Acid |
SNPs |
Single Nucleotide Polymorphisms |
FDA-NIH |
FDA-NIH Biomarker Working Group |
PD-L1 |
Programmed Death-Ligand 1 |
PD-1 |
Programmed Death-1 |
NKX2-1 |
Thyroid Transcription Factor-1 |
TTF-1 |
Thyroid Transcription Factor-1 |
NAPSA |
Napsin A |
CYFRA 21-1 |
Cytokeratin 19 fragment |
CEA |
Carcinoembryonic Antigen |
SCCA |
Squamous cell carcinoma antigen |
CA125 |
Carbohydrate antigen 125 |
miRNA |
microRNA |
FGFR1 |
Fibroblast Growth Factor Receptor 1 |
DDR2 |
Discoidin domain Receptor 2 |
m6A |
N6-methyladenine |
SFTA2 |
Surfactant Protein A2 |
ROS1 |
ROS Proto-Oncogene 1 |
ALK |
Anaplastic Lymphoma Kinase |
BRAF |
B-Raf Proto-Oncogene |
NTRK |
Neurotrophic Tyrosine Kinase Receptor |
TIM-3 |
T-cell Immunoglobulin and Mucin Domain Containing-3 |
TMB |
Tumor Mutational Burden |
AMP |
Association for Molecular Pathology |
CAP |
College of American Pathologists |
IASLC |
International Association for the Study of Lung Cancer |
ASCO |
American Society of Clinical Oncology |
ESMO |
European Society for Medical Oncology |
NCCN |
National Comprehensive Cancer Network |
VEGF |
Vascular Endothelial Growth Factor |
TUBB3 |
Tubulin Beta-3 |
KIAA1522 |
KIAA1522 protein |
TGF-β |
Transforming Growth Factor Beta |
LAG-3 |
Lymphocyte Activation Gene-3 |
NLR |
Neutrophil-to-Lymphocyte Ratio |
PLR |
Platelet-to-Lymphocyte Ratio |
PCA |
Principal Component Analysis |
t-SNE |
t-Distributed Stochastic Neighbor Embedding |
SVM |
Support Vector Machine |
qPCR |
Quantitative Polymerase Chain Reaction |
RT-PCR |
Reverse Transcription Polymerase Chain Reaction |
R |
Programming language/software for statistical computing and graphics |
LIMMA |
Linear Models for Microarray Data Analysis |
STRING |
Search Tool for the Retrieval of Interacting Genes/Proteins |
Cytoscape |
Software platform for visualizing molecular interaction networks |
DAVID |
Database for Annotation, Visualization, and Integrated Discovery |
KEGG |
Kyoto Encyclopedia of Genes and Genomes |
GO |
Gene Ontology |
GEPIA |
Gene Expression Profiling Interactive Analysis |
HPA |
The Human Protein Atlas |