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. 2023 Jul 3;15(13):3474. doi: 10.3390/cancers15133474
NSCLC Non-Small Cell Lung Cancer
PET Positron Emission Tomography
GEO Gene Expression Omnibus
TCGA The Cancer Genome Atlas
MDS Multidimensional Scaling
UMAP Uniform Manifold Approximation and Projection
TP53 Tumor Protein 53
EGFR Epidermal Growth Factor Receptor
ALK Anaplastic Lymphoma Kinase
MRI Magnetic Resonance Imaging
CT Computed Tomography
FISH Fluorescence In Situ Hybridization
PCR Polymerase Chain Reaction
IHC Immunohistochemistry
TKIs Tyrosine Kinase Inhibitors
OPN Osteopontin
PI3K/AKT/mTOR Phosphoinositide 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin
RET Rearranged during Transfection
JAK-STAT Janus Kinase-Signal Transducer and Activator of Transcription
RAS/MAPK Rat Sarcoma/Mitogen-Activated Protein Kinase
MET Mesenchymal Epithelial Transition
EMT Epithelial-Mesenchymal Transition
HER2 Human Epidermal Growth Factor Receptor 2
MEK/ERK Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase
BRAF B-Raf Proto-Oncogene, Serine/Threonine Kinase
ROS1 ROS Proto-Oncogene 1, Receptor Tyrosine Kinase
KRAS Kirsten Rat Sarcoma Viral Oncogene Homolog
NTRK Neurotrophic Tropomyosin Receptor Kinase
TME Tumor Microenvironment
ICBs Immune Checkpoint Inhibitors
STK11 Serine/Threonine Kinase 11
NGS Next-Generation Sequencing
TNM Tumor, Node, Metastasis
FDA U.S. Food and Drug Administration
NIH National Institutes of Health
DNA Deoxyribonucleic Acid
SNPs Single Nucleotide Polymorphisms
FDA-NIH FDA-NIH Biomarker Working Group
PD-L1 Programmed Death-Ligand 1
PD-1 Programmed Death-1
NKX2-1 Thyroid Transcription Factor-1
TTF-1 Thyroid Transcription Factor-1
NAPSA Napsin A
CYFRA 21-1 Cytokeratin 19 fragment
CEA Carcinoembryonic Antigen
SCCA Squamous cell carcinoma antigen
CA125 Carbohydrate antigen 125
miRNA microRNA
FGFR1 Fibroblast Growth Factor Receptor 1
DDR2 Discoidin domain Receptor 2
m6A N6-methyladenine
SFTA2 Surfactant Protein A2
ROS1 ROS Proto-Oncogene 1
ALK Anaplastic Lymphoma Kinase
BRAF B-Raf Proto-Oncogene
NTRK Neurotrophic Tyrosine Kinase Receptor
TIM-3 T-cell Immunoglobulin and Mucin Domain Containing-3
TMB Tumor Mutational Burden
AMP Association for Molecular Pathology
CAP College of American Pathologists
IASLC International Association for the Study of Lung Cancer
ASCO American Society of Clinical Oncology
ESMO European Society for Medical Oncology
NCCN National Comprehensive Cancer Network
VEGF Vascular Endothelial Growth Factor
TUBB3 Tubulin Beta-3
KIAA1522 KIAA1522 protein
TGF-β Transforming Growth Factor Beta
LAG-3 Lymphocyte Activation Gene-3
NLR Neutrophil-to-Lymphocyte Ratio
PLR Platelet-to-Lymphocyte Ratio
PCA Principal Component Analysis
t-SNE t-Distributed Stochastic Neighbor Embedding
SVM Support Vector Machine
qPCR Quantitative Polymerase Chain Reaction
RT-PCR Reverse Transcription Polymerase Chain Reaction
R Programming language/software for statistical computing and graphics
LIMMA Linear Models for Microarray Data Analysis
STRING Search Tool for the Retrieval of Interacting Genes/Proteins
Cytoscape Software platform for visualizing molecular interaction networks
DAVID Database for Annotation, Visualization, and Integrated Discovery
KEGG Kyoto Encyclopedia of Genes and Genomes
GO Gene Ontology
GEPIA Gene Expression Profiling Interactive Analysis
HPA The Human Protein Atlas