Table 5.
Relationship of responses to treatment to ECOG performance status, Katz scale, and the most frequently reported comorbidities.
| Variable | Level | Number of Patients n (%) |
Response to the Treatment Used n (%) | Independence Assessment p-Value |
||||
|---|---|---|---|---|---|---|---|---|
| Complete Remission (CR) |
Very Good Partial Response (VGPR) | Partial Response (PR) | Disease Stabilization (SD) | Disease Progression (PD) | ||||
|
ECOG scale
n = 197 (100%) |
0 | 16 | 2 (12.5%) | 2 (12.5%) | 8 (50.0%) | 1 (6.2%) | 3 (18.8%) | 0.642 |
| 1 | 84 | 11 (13.1%) | 7 (8.3%) | 43 (51.2%) | 16 (19.0%) | 7 (8.3%) | ||
| 2 | 71 | 5 (7.0%) | 5 (7.0%) | 43 (60.6%) | 14 (19.7%) | 4 (5.6%) | ||
| 3 | 18 | 0 (0%) | 1 (5.6%) | 12 (66.7%) | 3 (16.7%) | 2 (11.1%) | ||
| 4 | 8 | 0 (0%) | 0 (0%) | 4 (50.0%) | 2 (25.0%) | 2 (25.0%) | ||
|
Performance status, according to ADL (Katz)
n = 192 (97.5%) |
Fully independent | 158 | 16 (10.1%) | 15 (9.5%) | 89 (56.3%) | 26 (16.5%) | 12 (7.6%) | 0.097 |
| Moderately impairment | 23 | 2 (8.7%) | 0 (0%) | 13 (56.5%) | 7 (30.4%) | 1 (4.3%) | ||
| Completely dependent | 11 | 0 (0%) | 0 (0%) | 5 (45.5%) | 2 (18.2%) | 4 (36.4%) | ||
|
Number of comorbidities
n = 197 (100%) |
Four and more | 53 | 1 (1.9%) | 3 (5.7%) | 31 (58.5%) | 11 (20.8%) | 7 (13.2%) | 0.156 |
| Cardiovascular disease n = 197 | - | 166 | 13 (7.8%) | 13 (7.8%) | 92 (55.4%) | 31(18.7%) | 17 (10.2%) | 0.504 |
|
Kidney disease
n = 133 |
- | 48 | 2 (4.2%) |
2 (4.2%) |
27 (56.2%) |
11 (22.9%) |
26 (12.5%) |
0.388 |
|
Creatinine above 1.9 mg/dL
n = 197 |
- | 44 | 3(6.8%) | 2(4.5%) | 19 (43.2%) | 13 (29.5%) | 7 (15.9%) | 0.058 |
|
Diabetes
n = 196 |
- | 40 | 3 (7.5%) | 13 (8.3%|) | 21 (52.5%) | 9 (22.5%) | 5 (12.5%) | 0.753 |
|
Cerebral circulation disorders
n = 137 |
- | 18 | 0 (0%) | 1 (5.6%) | 14 (77.8%) | 0 (0%) | 3 (16.7%) | 0.018 |