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. 2023 Jul 1;15(13):3458. doi: 10.3390/cancers15133458

Figure 3.

Figure 3

Proposed therapeutic approach to target highly plastic GSCs in GBM. Highly plastic GBM requires multimodal and sequential therapeutic approaches. The first treatment (anti-GBM therapy) eliminates some cellular states while also driving cells (including GSCs) towards one single state. This post-treatment minimal residual disease (MRD) state exhibits greatly reduced heterogeneity and is now vulnerable to strategies specifically targeting the remaining cellular state. Created with BioRender.com (accessed on 22 June 2023).