Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
When cytokines (e.g., INF-γ) activate immune cells such as macrophages, cytokine receptors depend on JAK to activate the transcription factors of the STAT family. STAT promotes pro-inflammatory gene expression, resulting in, e.g., release of IL-23. JAK inhibitors prevent cytokine signaling at the beginning of the intracellular cascade. Created with biorender.com.
