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. 2023 Jun 26;12(13):1723. doi: 10.3390/cells12131723

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of blocking AQP4 on HOC-evoked increase in LRRC8A expression and its colocalization with GFAP in acute SON slices. (A,B). Confocal microscopy of immunohistochemistry of nuclei (DAPI; blue), GFAP (green), and LRRC8A (red) in (a), and at different times of HOC without (A) and with 10 μmol/L TGN-020 (B). Bar graphs summarizing the staining intensity of LRRC8A (b) and the MCC for GFAP and LRRC8A (c) at different times of HOC. Scale bars = 30 µm; in A, n = 6; *, p < 0.05, **, p < 0.01, and ***, p < 0.005 compared with 0 min HOC (ANOVA, Dunn); in (B), n = 10; ***, p < 0.005 compared with 0 min HOC; ###, p < 0.001 compared with 5 min HOC (ANOVA, Dunn). Abbreviations: LRRC8A, leucine-rich repeat-containing protein 8A; other annotations as in Figure 1 and Figure 4.