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. 2023 Jun 25;12(13):1718. doi: 10.3390/cells12131718

Figure 1.

Figure 1

Schematic representation of the synaptonemal complex (SC) based on recent interaction data between central element proteins and the transverse filament [25]. The SC assembly, facilitated by the central element (CE) region, provides a necessary three-dimensional framework for double-strand break (DSB) repair and crossover (CO) formation. This assembly process is directed by recombination intermediates that are enzymatically processed by dynamic macromolecular protein complexes called recombination nodules (RNs). The transverse filament (depicted in pink) is composed of a supramolecular SYCP1 tetramer lattice that binds parallel SYCP1 dimers together. It supports cooperative head-to-head interactions between the N-terminal interaction protein sites of bioriented SYCP1 tetramers, which are anchored to chromosome axes through the back-to-back assembly of their helical C-termini [26]. Strong interactions between central element proteins are depicted by the overlap between the ovals representing SYCE2–TEX12 and SYCE1–SIX6OS1. Weak interactions are shown as punctual contacts, with SYCE2 interacting with SYCE3 and SYCE1 interacting with SYCE3. The grey coiled lines represent DNA loops generated by the meiotic cohesin axes.