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. 2023 Jul 2;15(13):3466. doi: 10.3390/cancers15133466

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Regulation of itga6 mRNA by microRNAs (miR) and N6-methyladenosine modifications. (A) miR-143-3P degrades itga6 mRNA, and (B) in patients with salivary adenoid cystic carcinoma (SACC), the highly elevated levels of ADAMTS9-AS2, competitively bound to miR-143-3P, hinder itga6 miRNA-mediated degradation. (C) miR-448 targets and degrades ythdf3 and itga6. (D) On the other hand, the histone demethylase lysine-specific demethylase 5B (KDM5B), an overexpressed oncogene in the malignant phenotype of hepatocellular carcinoma (HCC), inhibits miR-448 expression and therefore protects itga6 degradation.