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. 2023 Jun 29;15(13):3420. doi: 10.3390/cancers15133420

Figure 1.

Figure 1

Distribution of pathogenic or likely pathogenic (P/LP) variants detected by NGS. (A) Distribution and percentages of the 530 (P/LP) variants detected in all HBOC cases. (B) Frequencies of (P/LP) variants in all HBOC cases. (C) Genes with (P/LP) variants detected in the 177 patients with breast cancer diagnosed before 31 years of age. (D) Genes with (P/LP) variants detected in the 759 patients with ovarian cancer. (E) Genes with (P/LP) variants detected in 91 patients with male breast cancer (F). Genes with (P/LP) variants detected in the 492 patients who had previously tested negative for BRCA pathogenic variants and retested using the GGC-HBOC gene panel.