Table 2.
Clinical data of the patients studied.
| Personal and Familial Criteria | Total | Detection Rate of P/LP Variants, n (%) |
|---|---|---|
| Breast carcinoma ≤ 31 years | 177 | 23 (13%) |
| Breast carcinoma ≤ 36 years | 564 | 23 (14%) |
| Male breast carcinoma | 91 | 11 (12%) |
| Ovary adenocarcinoma | 759 | 112 (15%) |
| Bilateral breast carcinoma | 244 | 33 (14%) |
| Free of cancer index case with a strong familial history of HBOC | 108 | 9 (8.3%) |
| Index case with both breast and ovarian cancer | 74 | 9 (17.6%) |
| Patients previously tested negative for BRCA pathogenic variants retested using the panel of 13 HBOC genes | 492 | 25 (5%) |
n: number of patients; %: percentage of patients; P/LP: pathogenic/likely pathogenic.