Fecal microbiome biodiversity was measured and is represented as box plots of species richness (A) and species evenness (B). Elements of alpha-diversity, measured by Simpson Index, which relates operational taxonomic unit (OTU) richness and evenness, are plotted with each box representing groups containing 5 mice (N = 5). TBI results in a marked decrease in the number of species present and their relative abundance. Post-TBI treatment with FMT abrogates TBI-induced decreases in richness and evenness. ((P ≤ 0.05(*), 0.001(**), and 0.0001(***)).