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. Author manuscript; available in PMC: 2023 Jul 13.
Published in final edited form as: Shock. 2022 Jun 1;57(6):251–259. doi: 10.1097/SHK.0000000000001934

Fig. 5. FMT attenuates cortical volume loss and preserves white matter connectivity after TBI.

Fig. 5.

(A) Representative longitudinal and transverse MRI scans of animals (60DPI) with injury sites indicated with red arrows (N = 3). (B) FMT attenuates TBI-induced ventriculomegaly (red arrows) which is a well-described surrogate for cortical volume loss (P < 0.002). (C) Images ktrans level (measure of capillary permeability) were extracted from contrast-enhanced 3D-MRI. Fractional anisotropy (connectivity) maps were then extracted from the MRI images. (D) TBI induced a decrease in fractional anisotropy (white matter connectivity) compared to sham injury (P < 0.0001). FMT treatment attenuated this loss of connectively as compared to vehicle treated TBI mice (P = 0.04).