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. 2023 Jun 23;24(13):10527. doi: 10.3390/ijms241310527

Figure 4.

Figure 4

MC-LR increased M2 macrophage infiltration and decreased the expression of CST3 to exacerbate tumor progression in AOM/DSS-model mice. (A) Gross macroscopic images of the colorectal tissues of mice in each group were represented (n = 10). The number of colorectal tumors in mice was counted. (B) Colorectal tumor tissues of mice were stained by H&E and the arrow indicates tumor infiltration (scale bar: 50 μm). Data were presented as the means ± SD (n = 10). * p < 0.05, compared with the control group. The IHC results of CRC tissues were shown in (C–F), and (G), which represent the expression of F4/80, CD163, CD206, TGF-β1, and CST3, respectively, and the arrows indicated the positive expression of corresponding measurement indicators (scale bar: 50 μm). Sequential representation: the control and the AOM/DSS group were treated with saline; and MC-LR/AOM/DSS group was treated with 40 μg/kg body weight MC-LR daily for 15 days.