Figure 5.

Human PMB mitochondrial DNA (mtDNA) copy numbers stratified by diagnosis and APOE genotype. Using PMB AD and control (CTRL) samples, mtDNA copy numbers were quantified by RT-qPCR (SYBR-based). mtDNA copy numbers are stratified by diagnosis (A) and alleles of APOE SNP rs429358 (B). The normalized ΔCt shows that a larger ∆Ct value indicates a greater number of mtDNA. p-values from a linear mixed effects model and pairwise comparison with the covariate, APOE ε4 status. c- indicates subjects with no ε4 alleles; c+ indicates subjects with at least one ε4 allele.