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. 2023 Jul 3;24(13):11035. doi: 10.3390/ijms241311035

Figure 7.

Figure 7

Intraperitoneal CCK-BR scFv attenuates mechanical hypersensitivity. The von Frey mechanical threshold was significantly increased toward baseline in male mice with FRICT-ION chronic neuropathic pain indicating reduction of pain. The 0.4, 4, and 40 mg/kg doses were effective in reducing mechanical hypersensitivity in a previous study [31]. In a separate study here, hypersensitivity was reduced with FRICT-ION trigeminal nerve irritation in both male (A) and female (B) mice with CCK-BR scFv given i.p. (4 mg/kg).