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. 2023 Jul 3;24(13):11035. doi: 10.3390/ijms241311035

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pre-Treatment is Not Efficacious. (A) Ipsilateral von Frey testing was not efficacious for reducing facial hypersensitivity if a pre-treatment (i.p.) with CCK-BR scFv was given once 3 weeks prior to FRICT-ION model induction. When a second dose was given in Week 3 after model induction, the same delayed, durable effect was seen as with the single dose at 3 weeks. (B) Multiple 4.0 mg/kg daily doses given to mice in week 3 had the same delayed but durable effect with a single dose ( daily dose given for 5 days, once a week, or every other week). (C) If scFv is given once, then hindpaw surgical cut performed three weeks later, the scFv had no effect compared to the vehicle.

Inline graphic — Pre-Treatment is Not Efficacious. (A) Ipsilateral von Frey testing was not efficacious for reducing facial hypersensitivity if a pre-treatment (i.p.) with CCK-BR scFv was given once 3 weeks prior to FRICT-ION model induction. When a second dose was given in Week 3 after model induction, the same delayed, durable effect was seen as with the single dose at 3 weeks. (B) Multiple 4.0 mg/kg daily doses given to mice in week 3 had the same delayed but durable effect with a single dose ( daily dose given for 5 days, once a week, or every other week). (C) If scFv is given once, then hindpaw surgical cut performed three weeks later, the scFv had no effect compared to the vehicle.