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. 2023 Jul 3;24(13):11035. doi: 10.3390/ijms241311035

Figure 11.

Figure 11

Efficacy for Anxiety Reduction in Mice–Zero Maze. (A,B) Comparisons for three of the CCK-BR scFvs were tested for effects on anxiety measures typically associated with chronic pain in male mice. The scFvs 14-3 and 77-2 were efficacious in improving the time spent in the open area of the maze compared to vehicle treated mice. All the scFvs improved the distance traveled around the maze. (C,D) Dose comparisons of the 77-2 CCK-BR scFv were tested for effects on anxiety measures typically associated with chronic pain in male mice. The 0.4, 4.0, and 40 mg/kg doses were efficacious in improving the time spent in the open area of the maze. There were no significant changes in distance traveled around the maze at any dose. (E,F) In female mice, there was improvement for time spent in open area. However, the distance traveled around the maze was significantly different from naïve and untreated mice. ANOVA * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.