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. 2023 Jul 3;24(13):11035. doi: 10.3390/ijms241311035

Figure 12.

Figure 12

Efficacy for Anxiety Reduction in Mice—Light/Dark Chamber. (A,B) Comparisons for three of the CCK-BR scFvs were tested for effects on anxiety measures typically associated with chronic pain in male mice. scFvs 14-3 showed a significant difference in the total rearing behaviors, but otherwise there were no significant changes in behavior. (C,D) Dose comparisons of the CCK-BR scFv were tested for effects on anxiety measures typically associated with chronic pain in male mice. The highest dose was efficacious in improving the amount of rearing behavior. There was an improvement with higher doses with more time spent in the light chamber. (E,F) In female mice, treated mice spent significantly more time in the light chamber and demonstrated rearing behaviors after treatment with the 4 mg/kg dose. ANOVA * p < 0.05, ** p < 0.01, *** p < 0.001.