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. 2023 Jun 22;24(13):10493. doi: 10.3390/ijms241310493

Figure 2.

Figure 2

Neutralization antibody titers (ID50 values) against SARS-CoV-2 variant pseudoviruses for pre- and post-boost sera from individuals primarily vaccinated with Sputnik V. Sera from the uninfected donors revaccinated with (A–C) Sputnik V or (D–F) Comirnaty. Sera from (G–I) convalescent donors revaccinated with Sputnik V. Asterisks indicate a significant difference when comparing ID50 values against the WT with variants. Connecting lines indicate serum from the same individual. (C,F,I) Summary of virus-neutralizing activities of serum samples against the WT and variants before (open bars) and after (solid bars) Sputnik/Comirnaty boost. Asterisks indicate a significant difference when comparing ID50 values before and after a boost for each variant. Colors of points and bars correspond to the variants: black–WT, red–Alpha, orange–Beta, green–Delta, violet–Omicron BA.1, pink–Omicron BA.4/BA.5. Medians ± IQR of ID50 values are shown. Statistical analysis was performed using the Friedman test and Dunn’s post hoc test, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns = not significant.