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. 2023 Jun 29;24(13):10858. doi: 10.3390/ijms241310858

Table 2.

Molecular targeted agents and immune checkpoint inhibitors for HCC.

Drug Target References
Tyrosine Kinase Inhibitors Sorafenib Almost 40 tyrosine kinases, such as c-RAF, B-RAF, VEGFR1-3, PDGFR-α/β, c-Kit, FLT-3, and RET [9,156,164]
Regorafenib c-RAF, wild-type and mutant (V600E) B-RAF, VEGFR1-3, FGFR1-2, PDGFR, KIT, RET, angiopoietin 1 receptor (TIE2), and p-38-α (greater potency to target VEGFR, KIT, TIE2, and RET compared to Sorafenib) [9,164,165]
Lenvatinib VEGFR1–3, FGFR1-4, PDGFR-α, KIT, and RET [9,15,164]
Cabozantinib VEGFR 1–3, KIT, RET, TIE2, FLT3, c-MET, and AXL [9,158,164]
VEGF Inhibitors Ramucirumab VEGFR-2 [9,159,164]
Bevacizumab VEGFR2 by binding VEGF-A [9,164,165]
Immune Checkpoint Inhibitor Atezolizumab PD-L1 [9,164,165]

c-RAF, c-rapidly accelerated fibrosarcoma; B-RAF, b-rapidly accelerated fibrosarcoma; VEGFR, vascular endothelial growth factor receptor; PDGFR-α/β, platelet-derived growth factor receptor-α/β; FLT-3, fms like tyrosine kinase 3; RET, rearranged during transfection; FGFR1-4, fibroblast growth factor receptors 1-4; TIE2, tyrosine kinase with immunoglobulin-like and EGF-like domains; VEGFA, vascular endothelial growth factor A; PD-L1, programmed death-ligand 1.