Figure 2b:

Images illustrate gross appearance of rat colon in (a) acute inflammation cohort, (b) phosphate-buffered saline–negative control cohort, and (c) fibrotic cohort. In a, distal colon and rectum are thick walled and markedly inflamed (arrowheads), while more proximal colon, including the cecum (*), is normal. In b, the entire colon is normal, and fecal material is present within the mid and distal colon. In c, distal colon and rectum are thick walled (arrowheads) without appreciable inflammation. The more proximal colon is normal. Longitudinal section (inset) of the fibrotic region shows substantial bowel wall thickening.